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Frédéric Lagarrigue

Position

CNRS Research associate (CRCN) in immunology
Institute of Pharmacology and Structural Biology (IPBS-UMR 5089)
205 route de Narbonne, 31077 Toulouse cedex 04, France 

orcid.org/0000-0002-4660-8666
www.linkedin.com/in/frederic-lagarrigue/


Background

From the beginning of my career, I have been interested in better understanding the diseases at the molecular level. I received my PhD in cancer biology from the Toulouse University in 2011. My dissertation work in the lab of Bernard Payrastre at the Center for Physiopathology of Toulouse Purpan dealt with the cellular function of the lipid second messenger phosphoinositides in the context of Shigella flexneri infection, which is responsible for the dysentery in humans, and invasion of anaplastic large cell lymphomas. I then joined the lab of Mark Ginsberg at the University of California San Diego, where I conducted work on signaling events that control the affinity of the integrin adhesion receptors for their cognate ligands, an event central to their function in blood cells. This postdoctoral stage (2012-2018) was sponsored in part by a Postdoctoral fellowship and a Career Development award from the American Heart Association. My work led to establish the emerging paradigm that signaling events in leukocytes operate in both a cell-type and integrin-specific manner, thereby providing unique avenues to manipulate recruitment of particular leukocytes into specific tissues. In 2019, I was recruited to CNRS as a permanent researcher to work on integrin-mediated adhesion in immune cells in the lab of Isabelle Maridonneau-Parini at IPBS. My research program received financial supports from the Fondation de France, Fondation Toulouse Cancer Santé and a Marie Sklodowska-Curie Individual Fellowship – Reintegration panel. In 2021, I was awarded the ATIP-Avenir funding program in partnership with the Fondation ARC to launch my own research team on the dynamic regulation of immune cell integrins and the interplay with cancer pathogenesis and chronic inflammatory diseases at IPBS.

 

Scientific activity

My scientific achievements consist of 17 original research articles and 2 literature reviews, accumulating over 600 citations according to Google Scholar https://scholar.google.com/citations?user=RkeuP6QAAAAJ&hl=fr


Prizes and Honors

•    « Doctoral and Research Supervision Award » (PEDR) from the CNRS, 2019-2022

•    « Young Investigator Award » from the Fondation FONROGA to honor all my research work in the field of integrin biology, 2019 
The Fondation FONROGA is dedicated to support and promote culture and health


Selected Publications 

•    Lagarrigue F*, Paul DS*, Gingras AR* et al. (2020) Talin-1 is the principal platelet Rap1 effector of integrin activation. Blood 136:1180-1190. https://pubmed-ncbi-nlm-nih-gov.insb.bib.cnrs.fr/32518959/

•    Gingras AR*, Lagarrigue F*, Cuevas MN et al. (2019) Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. J Cell Biol 218:1799-1809. https://pubmed-ncbi-nlm-nih-gov.insb.bib.cnrs.fr/30988001/

•    Lagarrigue F, Gingras AR, Paul DS et al. (2018) Rap1 binding to the talin1 F0 domain makes a minimal contribution to murine platelet GPIIb-IIIa activation. Blood Adv 2:2358-2368. https://pubmed-ncbi-nlm-nih-gov.insb.bib.cnrs.fr/30242097/

•    Lagarrigue F, Gertler FB, Ginsberg MH et al. (2017) Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes. J Immunol 198:3410-3415. https://pubmed-ncbi-nlm-nih-gov.insb.bib.cnrs.fr/28348273/

•    Lagarrigue F*, Vikas Anekal P*, Lee HS et al. (2015) Bachir AI, Ablack JN, Horwitz AF, Ginsberg MH. A RIAM/lamellipodin-talin-integrin complex forms the tip of sticky fingers that guide cell migration. Nat Commun 6:8492. https://pubmed-ncbi-nlm-nih-gov.insb.bib.cnrs.fr/26419705/